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Known all over the world for its consciousness-altering properties, marijuana is reported to reduce involuntary muscle contractions experienced by some people with Multiple Sclerosis. Users of this renowned drug, that is derived from the flowering top of the hemp plant, cannabis sativa, have claimed that marijuana reportedly alleviated some of their Multiple Sclerosis symptoms.

Reports that marijuana diminished Multiple Sclerosis involuntary muscle spasms led to a small number of clinical trials conducted to determine if a potential drug or other medical treatment might actually help sufferers.

Initial clinical research determined the function of tetrahydrocannabinol (THC), an active ingredient in marijuana, relating to the treatment of muscle spasms, tremor, and balance control in a restricted numbers of people afflicted with Multiple Sclerosis. However, the results of the reports are inconclusive, and clinical subjects experienced varied side effects.

However, the studies of the effect of THC to alleviate involuntary muscle spasms reveal contrasting results. Although some people reported feeling considerably relaxed and so became less prone to involuntary muscle spasms, the observable fact can not be specifically confirmed by objective testing. The results show that the analgesic effects of marijuana lasted no more than 3 hours and in increased doses corollary reactions of weakness, thirst, lightheadedness, short-term memory loss, spatial and time distortions, and lack of motor control have been reported.

In a study of THC regarding 8 seriously disabled men and women with advanced tremor and lack of muscle control, two subjects reported considerable improvement with tremor, which was verified by a doctor's examination although 3 reported improvement that could not be verified. Each of the eight subjects that were administered THC reported experiencing a high, while two reported sensations of uneasiness and restlessness.

A limited research on the effect of marijuana also revealed that the drug undermines motor coordination in posture control and equilibrium of individuals hurting from Multiple Sclerosis as well as those that did not have Multiple Sclerosis, with all subjects reporting feelings of giddiness.

The National Academy of Science/Institute of Medicine issued a report on March 17, 1999 that the medical uses of marijuana raised additional questions. Though the report did conclude that smoking marijuana does not have a direct part in the treatment of Multiple Sclerosis, the possibility exists that specific compounds derived from marijuana could possibly alleviate some Multiple Sclerosis related symptoms, particularly those related to involuntary muscle spasms. The report recommends that scientific and controlled studies of the curative potential of cannabin compounds be undertaken combined with the safe development and dependable drug delivery tools.

Medical researchers have tested the capability of 2 derivatives from marijuana called cannabin and 3 synthetic cannabins to control unconscious muscle contractions and tremor, symptoms of the Multiple Sclerosis-like disease, in mice. The findings suggest that 4 different cannabins could possibly temporarily relieve involuntary muscle spasms and/or tremor. Although the study recommended that derivatives of marijuana might be developed for human use, the primary obstacle would be to determine the right amount of these cannabins to make sure they are a safe and workable treatment for those who have Multiple Sclerosis.

Using the results of studies accomplished to date as a starting point, the National Multiple Sclerosis Society's Medical Advisory Board states that there are presently insufficient conclusive data to warrant the recommendation of marijuana or its derivatives to be a treatment for people afflicted with Multiple Sclerosis and that extended use could cause considerable serious side effects.

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